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doi: 10.1111/j.1742-4658.2007.05774.x 95 ZouYPalteMJDeikAALiHEatonJKWangWet al

Enhanced J-protein interaction and compromised protein stability of mtHsp70 variants lead to mitochondrial dysfunction in Parkinsons disease

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This calculus matters for conditions requiring strong systemic effects

The GLP-1 revolution has transformed weight management, but many users discover that losing 15-20% of body weight comes with unintended consequences, including loss of lean muscle mass that can reach 25-40% of total weight lost

586,587 Similarly, reactive astrocytes are associated with -amyloid deposits in the brains of various transgenic AD models (most of which are models of hyperamyloidosis), although sometimes reactive remodelling of astrocytes precedes formation of -amyloid plaques