This protective property ensures that peptide solutions remain uncontaminated and research-ready throughout their intended period of use
This is really helpful for people suffering from gut issues where the absorption of oral supplements may not be 100%
In addition, if you're one the millions of Americans taking proton pump inhibitors, known as PPI's, that suppress stomach acid for conditions like acid reflux, you're going to be prone to Vitamin B12 deficiency
Less acid means less available B12
Because nicotinamide would otherwise re-enter the NAD+ salvage pathway through NAMPT and NMN, NNMT activity sits at a junction between cellular methylation capacity and NAD+ regeneration, which is why the enzyme became a target after Kraus and colleagues (Nature, 2014) reported the consequences of antisense Nnmt knockdown in white adipose tissue and liver
Reviewed by FDA against compounding inclusion in December 2024