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In addition to being regulated by enzymes involved in the synthetic pathway, the metabolic pathway is also regulated by the MYB family of transcription factors

Patients with autoimmune diseases frequently require treatment for type 2 diabetes or obesity, conditions that occur at higher rates in certain autoimmune populations

All clinical trials Phase 1, Phase 2, and the Phase 3 TRIUMPH program used once-weekly dosing exclusively

Inflammation may also play an important role in the development of complications that arise in patients with type 2 diabetes