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Additionally, the GLP-1R/GCGR dual agonist TB001 alleviates liver fibrosis by inhibiting the TGF-/Smad2/3 signaling pathway and hepatic stellate cell activation, while modulating NF-B and JNK pathways to suppress inflammation and apoptosis (159)
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During hyperglycaemia, the inhibitory mechanism predominates, so the weak stimulatory effect of GIP is mainly visible at lower glucose levels [30]
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