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However, completely absent progress after 8-12 weeks suggests either ineffective protocol or injury severity beyond peptide intervention requiring medical evaluation

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Iron accumulation, a hallmark of ferroptosis, can be modulated by NRF2-regulated genes involved in iron storage and transport [40]

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Nanoparticle-based delivery systems, including liposomes, polymeric micelles, PEGylated constructs, and PLGA nanoparticles, can bypass efflux recognition and enhance tumor-selective drug accumulation, thereby restoring therapeutic efficacy