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At first glance, it may seem like higher oral doses would work better, but evidence suggests that is not always true
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Neurochem J 15(2):114128 Bachstetter AD, Van Eldik LJ (2010) The p38 MAP kinase family as regulators of proinflammatory cytokine production in degenerative diseases of the CNS
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doi: 10.1093/pm/pny047
This led to a reduction in the expression of the fibrosis genes actin-alpha-2 (ACTA2) and collagen-type-1-alpha-1 (COL1A1) in the kidneys, suggesting that the inhibitor may have therapeutic promise for treating renal fibrosis[83]
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