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Elevated levels of extracellular glutamate lead to the overactivation of Ca 2+ -permeable NMDARs, subsequent Ca 2+ overload, and excitotoxicity (Figure 1
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The FDA's 503A framework also requires bulk substances used by compounders to meet applicable standards and be accompanied by a valid certificate of analysis, with the agency advising compounders to scrutinise their bulk-drug suppliers
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